Relaxants

Relaxants

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Vladimir Nigrovic, Shashi B. Bhatt and Anton Amann (2007)
Simulation of the reversal of neuromuscular block by sequestration of the free molecules of the muscle relaxant
Journal of Pharmacokinetics and Pharmacodynamics 34: 771-788

Bhatt SB, Amann A and Nigrovic V (2007)
Onset-potency relationship of nondepolarizing muscle relaxants: a reexamination using simulations
Can J Physiol Pharmacol 85: 774-82.

Bhatt SB, Kohl J, Amann A, Nigrovic V (2007)
The relationship between twitch depression and twitch fade during neuromuscular block produced by vecuronium: correlation with the release of acetylcholine
Theoret Biol Medical Modelling 4, 24.

Nigrovic V, Amann A, Bhatt B (2006)
Modeling of twitch fade based on slow interaction of nondepolarizing muscle relaxants with the presynaptic receptors
Journal of Pharmacokinetics and Pharmacodynamics 33, 461 − 483.

Vladimir Nigrovic, Anton Amann, Shashi Bhatt (2005)
Myasthenia gravis and myasthenic syndrome: Simulation of twitch strength and neuromuscular block
Muscle & Nerve 32, 745-750

Nigrovic V, Proost JH, Amann A, and Bhatt SB (2005)
Volume of the effect compartment in simulations of neuromuscular block.
Theoretical Biology and Medical Modelling 2, 41.

Nigrovic V, Amann A, Bengez R
Analysis of the pharmacodynamic parameters in a model for neuromuscular block
Med Sci Monit 2004; 10: BR468-476

Nigrovic V, Amann A (2004)
Simulation of interaction between two non-depolarizing muscle relaxants: generation of an additive or a supra-additive neuromuscular block
Journal of Pharmacokinetics and Pharmacodynamics 31: 157-179

Nigrovic V, Amann A (2004)
Time to maximum effect site concentration
Anesthesiology (Letter to the Editor) 100: 1319

Nigrovic V., Amann A. (2003)
Competition Between Acetylcholine and a Nondepolarizing Muscle Relaxant for Binding to the Postsynaptic Receptors at the Motor End Plate: Simulation of Twitch Strength and Neuromuscular Block
Journal of Pharmacokinetics and Pharmacodynamics 30: 23-51

Nigrovic V., Amann A. (2002)
Physiologic-Pharmacologic Interpretation of The Constants in The Hill Equation for Neuromuscular Block: An Hypothesis.
Journal of Pharmacokinetics and Pharmacodynamics 29: 189-206